High Incidence of Occult Leptomeningeal Disease Detected by Flow Cytometry in Newly Diagnosed Aggressive B-Cell Lymphomas at Risk of Central Nervous System Involvement: The Role of Flow Cytometry versus Cytology
نویسندگان
چکیده
From Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD. Address correspondence to: Wyndham H. Wilson, M.D., Ph.D., Experimental Transplantation and Immunology Branch, CCR, NCI, Building 10, Room 12-N-226, Bethesda, MD, 20892-1868. (Office) 301-435-2415; (Fax) 301-402-2359; (e-mail) [email protected]. Word Count: 4125. Running title: Occult leptomeningeal lymphoma detected by flow cytometry.
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytology
We assessed the cerebrospinal fluid (CSF) by flow cytometry and cytology in 51 newly diagnosed and 9 treated aggressive B-cell lymphomas at risk for central nervous system (CNS) involvement to examine the utility of flow cytometry, incidence of CSF disease, and clinical surrogates of CNS spread. Multicolor flow cytometry using multiple antibody panels for light chains and Band T-cell antigens i...
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The benefit of intrathecal therapy and systemic rituximab on the outcome of diffuse large B-cell lymphoma at risk of central nervous system disease is controversial. Furthermore, the effect of intrathecal treatment and rituximab in diffuse large B-cell and Burkitt lymphoma with occult leptomeningeal disease detected by flow cytometry at diagnosis is unknown. Untreated diffuse large B-cell (n=24...
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BACKGROUND Central nervous system (CNS) relapse is an uncommon but dramatic complication of diffuse large B-cell lymphoma (DLBCL). Several studies have demonstrated the superiority of cerebrospinal fluid (CSF) flow cytometry (FCM), as compared with conventional cytology (CC), in detecting occult leptomeningeal disease. The clinical relevance of a positive FCM still has to be clarified. PATIEN...
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